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And in 1951 the Upjohn Company found a cheap method for altering the molecular structure of the steroid. This meant an increased demand for barbasco-derived progesterone that could now be used as an intermediate materials for the production of cortisone. Syntex thrived in the course of the 1960s Technology news, however by the mid-1970s steroid hormone manufacturing was once again controlled by foreign enterprises and exports had shrunk from 545 kilos in 1969 to 260 pounds in 1976. Paris was the primary victim of a bombing raid; a German plane dropped four bombs on August 30, 1914.